Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy.

@article{Colombo2002TransplantationOA,
  title={Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy.},
  author={Carlo Colombo and Jaime J Cutson and Toshimasa Yamauchi and Charles Vinson and Takashi Kadowaki and Oksana Gavrilova and Marc L Reitman},
  journal={Diabetes},
  year={2002},
  volume={51 9},
  pages={
          2727-33
        }
}
Severe adipose tissue deficiency (lipoatrophy) causes insulin-resistant diabetes, elevated serum triglyceride and fatty acid levels, and massive triglyceride deposition in the liver. In lipoatrophic A-ZIP/F-1 mice, transplantation of normal adipose tissue greatly improved these parameters, whereas 1 week of leptin infusion had more modest effects. In contrast, leptin infusion was strikingly more effective in the aP2-n sterol response element binding protein 1 lipoatrophic mouse. Here we show… CONTINUE READING

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