Transplantation of a human liver following 3 days of ex situ normothermic preservation.

  title={Transplantation of a human liver following 3 days of ex situ normothermic preservation.},
  author={Pierre-Alain Clavien and Philipp Dutkowski and Matteo Mueller and Dilmurodjon Eshmuminov and Lucia Bautista Borrego and Achim Weber and Beat Muellhaupt and Richard X Sousa Da Silva and Brian R Burg and Philipp Rudolf von Rohr and Martin J Schuler and Dustin Becker and Max Hefti and Mark W. Tibbitt},
  journal={Nature biotechnology},
Current organ preservation methods provide a narrow window (usually <12 hours) to assess, transport and implant donor grafts for human transplantation. Here we report the transplantation of a human liver discarded by all centers, which could be preserved for several days using ex situ normothermic machine perfusion. The transplanted liver exhibited normal function, with minimal reperfusion injury and the need for only a minimal immunosuppressive regimen. The patient rapidly recovered a normal… 

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