Transplantation of X-linked severe combined immunodeficient dogs with CD34+ bone marrow cells.

@article{Hartnett2002TransplantationOX,
  title={Transplantation of X-linked severe combined immunodeficient dogs with CD34+ bone marrow cells.},
  author={Brian Hartnett and Dapeng Yao and Steven E. Suter and Norman Matthew Ellinwood and Paula S. Henthorn and Peter E Moore and Peter A. Mcsweeney and Richard A. Nash and Jeffrey D. Brown and Kenneth I. Weinberg and Peter John Felsburg},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2002},
  volume={8 4},
  pages={188-97}
}
X-linked severe combined immunodeficiency (X-SCID) is the most common form of human SCID and is caused by mutations in the common gamma chain (gammac), a shared component of the interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 receptors. BMT for human X-SCID results in engraftment of donor T-cells and reconstitution of normal T-cell function but engraftment of few, if any, donor B-cells and poor reconstitution of humoral immune function. Canine X-SCID is also caused by mutations in the yc… CONTINUE READING