Transplantation of Human Neural Progenitor Cells Expressing IGF-1 Enhances Retinal Ganglion Cell Survival

@inproceedings{Ma2015TransplantationOH,
  title={Transplantation of Human Neural Progenitor Cells Expressing IGF-1 Enhances Retinal Ganglion Cell Survival},
  author={Jie Ma and Chenying Guo and Caiwei Guo and Yu Sun and Tiffany Liao and Ursula Beattie and Francisco J. L{\'o}pez and Dong Feng Chen and Kameran Lashkari},
  booktitle={PloS one},
  year={2015}
}
We have previously characterized human neuronal progenitor cells (hNP) that can adopt a retinal ganglion cell (RGC)-like morphology within the RGC and nerve fiber layers of the retina. In an effort to determine whether hNPs could be used a candidate cells for targeted delivery of neurotrophic factors (NTFs), we evaluated whether hNPs transfected with an vector that expresses IGF-1 in the form of a fusion protein with tdTomato (TD), would increase RGC survival in vitro and confer neuroprotective… CONTINUE READING
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