Transplantation of Flk-1+ human bone marrow-derived mesenchymal stem cells promotes angiogenesis and neurogenesis after cerebral ischemia in rats.

@article{Bao2011TransplantationOF,
  title={Transplantation of Flk-1+ human bone marrow-derived mesenchymal stem cells promotes angiogenesis and neurogenesis after cerebral ischemia in rats.},
  author={Xinjie Bao and M. Feng and Junji Wei and Qin Han and Hao Zhao and Guilin Li and Zhaohui Zhu and Haiqun Xing and Yi-hua An and Chuan Qin and Robert Chunhua Zhao and Renzhi Wang},
  journal={The European journal of neuroscience},
  year={2011},
  volume={34 1},
  pages={
          87-98
        }
}
Transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) is a potential therapy for cerebral ischemia. Although BMSCs-induced angiogenesis is considered important for neurological functional recovery, the neurorestorative mechanisms are not fully understood. We examined whether BMSCs-induced angiogenesis enhances cerebral tissue perfusion and creates a suitable microenvironment within the ischemic brain, which in turn accelerates endogenous neurogenesis and leads to improved… CONTINUE READING
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