Transplantation of Expanded Fetal Intestinal Progenitors Contributes to Colon Regeneration after Injury

@inproceedings{Fordham2013TransplantationOE,
  title={Transplantation of Expanded Fetal Intestinal Progenitors Contributes to Colon Regeneration after Injury},
  author={Robert P. Fordham and Shiro Yui and Nicholas R.F. Hannan and Christoffer Soendergaard and Alison Madgwick and Pawel J. Schweiger and Ole Haagen Nielsen and Ludovic Vallier and Roger A. Pedersen and Tetsuya Nakamura and Mamoru Watanabe and Kim Bak Jensen},
  booktitle={Cell stem cell},
  year={2013}
}
Regeneration and homeostasis in the adult intestinal epithelium is driven by proliferative resident stem cells, whose functional properties during organismal development are largely unknown. Here, we show that human and mouse fetal intestine contains proliferative, immature progenitors, which can be expanded in vitro as Fetal Enterospheres (FEnS). A highly similar progenitor population can be established during intestinal differentiation of human induced pluripotent stem cells. Established… CONTINUE READING

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Following transplantation in a colonic injury model , FEnS contribute to regeneration of colonic epithelium by forming epithelial crypt - like structures expressing region - specific differentiation markers .
Following transplantation in a colonic injury model , FEnS contribute to regeneration of colonic epithelium by forming epithelial crypt - like structures expressing region - specific differentiation markers .
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