Transplantation of Bone Marrow–Derived Mesenchymal Stem Cells Improves Diabetic Polyneuropathy in Rats

@article{Shibata2008TransplantationOB,
  title={Transplantation of Bone Marrow–Derived Mesenchymal Stem Cells Improves Diabetic Polyneuropathy in Rats},
  author={Taiga Shibata and Keiko Naruse and Hideki Kamiya and Mika Kozakae and Masaki Kondo and Yutaka Yasuda and Nobuhisa Nakamura and Kimiko Ota and Takahiro Tosaki and Takashi Matsuki and Eitaro Nakashima and Yoji Hamada and Yutaka Oiso and Jiro Nakamura},
  journal={Diabetes},
  year={2008},
  volume={57},
  pages={3099 - 3107}
}
OBJECTIVE Mesenchymal stem cells (MSCs) have been reported to secrete various cytokines that exhibit angiogenic and neurosupportive effects. This study was conducted to investigate the effects of MSC transplantation on diabetic polyneuropathy (DPN) in rats. RESEARCH DESIGN AND METHODS MSCs were isolated from bone marrow of adult rats and transplanted into hind limb skeletal muscles of rats with an 8-week duration of streptozotocin (STZ)-induced diabetes or age-matched normal rats by… CONTINUE READING
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Diabetic neuropathy—a review

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