Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice

@inproceedings{Tucker2011TransplantationOA,
  title={Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice},
  author={Budd A Tucker and In-Hyun Park and Sara D. Qi and Henry J. Klassen and Caihui Jiang and Jing Yao and Stephen Michael Redenti and George Q. Daley and Michael Joseph Young},
  booktitle={PloS one},
  year={2011}
}
This study was designed to determine whether adult mouse induced pluripotent stem cells (iPSCs), could be used to produce retinal precursors and subsequently photoreceptor cells for retinal transplantation to restore retinal function in degenerative hosts. iPSCs were generated using adult dsRed mouse dermal fibroblasts via retroviral induction of the transcription factors Oct4, Sox2, KLF4 and c-Myc. As with normal mouse ES cells, adult dsRed iPSCs expressed the pluripotency genes SSEA1, Oct4… CONTINUE READING

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When tested using calcium imaging these cells were shown to exhibit characteristics of normal retinal physiology , responding to delivery of neurotransmitters .
When tested using calcium imaging these cells were shown to exhibit characteristics of normal retinal physiology , responding to delivery of neurotransmitters .
When tested using calcium imaging these cells were shown to exhibit characteristics of normal retinal physiology , responding to delivery of neurotransmitters .
Transplantation of Adult Mouse iPS Cell - Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice .
When tested using calcium imaging these cells were shown to exhibit characteristics of normal retinal physiology , responding to delivery of neurotransmitters .
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