Transplantation Tolerance and Autoimmunity After Xenogeneic Thymus Transplantation1

@article{Xia2001TransplantationTA,
  title={Transplantation Tolerance and Autoimmunity After Xenogeneic Thymus Transplantation1},
  author={Guliang Xia and Jozef Goebels and Omer Rutgeerts and Michel Vandeputte and Mark Waer},
  journal={The Journal of Immunology},
  year={2001},
  volume={166},
  pages={1843 - 1854}
}
Successful grafting of vascularized xenografts (Xgs) depends on the ability to reliably induce both T cell-independent and -dependent immune tolerance. After temporary NK cell depletion, B cell suppression, and pretransplant infusion of donor Ags, athymic rats simultaneously transplanted with hamster heart and thymus Xgs developed immunocompetent rat-derived T cells that tolerated the hamster Xgs but provoked multiple-organ autoimmunity. The autoimmune syndrome was probably due to an… 

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