Transplantation: Increased mortality risk in renal transplant recipients with ATG-induced CD4+ T-cell lymphopenia

Abstract

Prolonged CD4+ t-cell lymphopenia induced by the administration of polyclonal antithymocyte globulins (atGs) is an independent risk factor for death in renal transplant recipients, according to researchers in France. Polyclonal atGs, which cause t-cell depletion, are commonly used in immunosuppressive regimens in transplant recipients. although t-cell regeneration usually occurs following transplantation, long-term decreases in CD4+ t cells and increases in CD8+ t cells can occur. Didier Ducloux and colleagues had previously found that renal transplant recipients with impaired CD4+ t-cell reconstitution were at increased risk of atherosclerotic events, late opportunistic infections and cancer, but the effect on patient survival was unknown. in the current study, Ducloux et al. analyzed a previously described cohort of 302 stable renal transplant recipients transplantation

DOI: 10.1038/nrneph.2010.74

Cite this paper

@article{Ireland2010TransplantationIM, title={Transplantation: Increased mortality risk in renal transplant recipients with ATG-induced CD4+ T-cell lymphopenia}, author={Rebecca Ireland}, journal={Nature Reviews Nephrology}, year={2010}, volume={6}, pages={386-386} }