Transplantation: Epithelial-to-mesenchymal transition: a biomarker of ciclosporin-induced nephrotoxicity

@article{Myrvang2011TransplantationET,
  title={Transplantation: Epithelial-to-mesenchymal transition: a biomarker of ciclosporin-induced nephrotoxicity},
  author={Helene K. Myrvang},
  journal={Nature Reviews Nephrology},
  year={2011},
  volume={7},
  pages={488-488}
}
The degree to which use of calcineurin inhibitors is associated with the development of interstitial fibrosis and tubular atrophy is a matter of debate. A retrospective analysis of a randomized, controlled trial (RCT) now shows that the intensity of expression of two markers of epithelial-to-mesenchymal transition (EMT)—vimentin and β-catenin—can identify ciclosporin-treated kidney transplant recipients at risk of fibrogenesis and a decline in graft function. “EMT is a generic response of the… CONTINUE READING