Transplantable sites confer calcium sensitivity to BK channels

  title={Transplantable sites confer calcium sensitivity to BK channels},
  author={Matthew Schreiber and Alex Yuan and Lawrence Salkoff},
  journal={Nature Neuroscience},
Both intracellular calcium and voltage activate Slo1, a high-conductance potassium channel, linking calcium with electrical excitability. Using molecular techniques, we created a calcium-insensitive variant of this channel gated by voltage alone. Calcium sensitivity was restored by adding back small portions of the carboxyl (C)-terminal 'tail' domain. Two separate regions of the tail independently conferred different degrees of calcium sensitivity; together, they restored essentially wild-type… CONTINUE READING


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