Transplant genetics and genomics

@article{Yang2017TransplantGA,
  title={Transplant genetics and genomics},
  author={Joshua Y. C. Yang and Minnie M. Sarwal},
  journal={Nature Reviews Genetics},
  year={2017},
  volume={18},
  pages={309-326}
}
Ever since the discovery of the major histocompatibility complex, scientific and clinical understanding in the field of transplantation has been advanced through genetic and genomic studies. Candidate-gene approaches and recent genome-wide association studies (GWAS) have enabled a deeper understanding of the complex interplay of the donor–recipient interactions that lead to transplant tolerance or rejection. Genetic analysis in transplantation, when linked to demographic and clinical outcomes… 
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Genetic background and transplantation outcomes: insights from genome-wide association studies.
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Recent advances in the genetic studies of transplantation outcomes are summarized, including new genome-wide association studies for acute rejection, allograft survival, pharmacogenomics, and common transplant comorbidities.
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The ways in which genetic testing may be applied to improve the care of kidney transplant recipients and donors are explored.
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A number of the key advances in genomics which are relevant for heart transplant outcomes are summarized, and the translational potential that such knowledge may bring to patient care within the next decade is highlighted.
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This Review explores the mechanistic links underlying the associations between HLA and kidney diseases and discusses how these links might provide insights into disease pathogenesis and describe the clinical implications of these insights.
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The spectrum of nephrogenetic disorders is reviewed, the optimal approach to genetic testing is considered, the clinical utility of obtaining a molecular diagnosis is explored, the challenges of variant interpretation are reflected, and the future of this dynamic field is looked to.
Development and evaluation of a transfusion medicine genome wide genotyping array
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A transfusion medicine array (TM‐Array) is designed for study of both common and rare transfusion‐relevant variations in genetically diverse donor and recipient populations.
An accessible insight into genetic findings for transplantation recipients with suspected genetic kidney disease
TLDR
Trio-ES was conducted for the families who had multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early onset or extrarenal features, and detected promising variants of uncertain significance in candidate genes associated with renal development or renal disease.
A Multi-Marker Test for Analyzing Paired Genetic Data in Transplantation
TLDR
A multi-marker Joint Score Test (JST) to jointly test for association between recipient genotype SNP effects and a gene-based matching score with transplant outcomes and is competitive when compared with existing methods, such as the sequence kernel association test (SKAT).
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