Transplant-finalized salvage of adult acute lymphoblastic leukemia: results of a mitoxantrone- and methotrexate-based regimen in 36 patients.

@article{Bona2005TransplantfinalizedSO,
  title={Transplant-finalized salvage of adult acute lymphoblastic leukemia: results of a mitoxantrone- and methotrexate-based regimen in 36 patients.},
  author={Eros di Bona and Enrico Maria Pogliani and Giuseppe Rossi and Teresa Lerede and A D'emilio and Michele Vespignani and Francesco Rodeghiero and Tiziano Barbui and Renato Bassan},
  journal={Leukemia & lymphoma},
  year={2005},
  volume={46 6},
  pages={
          879-84
        }
}
Idarubicin-based induction programs in acute lymphoblastic leukemia (ALL) account for 75?-?85% of complete remission rate. A small amount of patients exhibit primary refractoriness, and approximately 60% of those achieving a remission eventually relapse. The present study aimed to review the outcome of patients relapsing after or resistant to an idarubicin-based, induction-consolidation regimen (with/without additional high dose cytarabine). The 'ABC' phase II trial consisted of mitoxantrone… CONTINUE READING