Transplacental transfer of Azithromycin and its use for eradicating intra-amniotic ureaplasma infection in a primate model.

@article{Acosta2014TransplacentalTO,
  title={Transplacental transfer of Azithromycin and its use for eradicating intra-amniotic ureaplasma infection in a primate model.},
  author={E. Pi{\~n}eiro Acosta and Peta L Grigsby and Kajal B. Larson and Amanda Marie James and Mary C Long and Lynn B. Duffy and Ken B. Waites and Miles J. Novy},
  journal={The Journal of infectious diseases},
  year={2014},
  volume={209 6},
  pages={
          898-904
        }
}
BACKGROUND Our goals were to describe azithromycin (AZI) pharmacokinetics in maternal plasma (MP), fetal plasma (FP), and amniotic fluid (AF) following intra-amniotic infection (IAI) with Ureaplasma in pregnant rhesus monkeys and to explore concentration-response relationships. METHODS Following intra-amniotic inoculation of Ureaplasma parvum, rhesus monkeys received AZI (12.5 mg/kg every 12 hours intravenously for 10 days; n = 10). Intensive pharmacokinetic sampling of MP, FP, and AF was… CONTINUE READING

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