Transplacental transfer and metabolism of 17-alpha-hydroxyprogesterone caproate.

  title={Transplacental transfer and metabolism of 17-alpha-hydroxyprogesterone caproate.},
  author={Sarah J Hemauer and Ru Yan and Svetlana L Patrikeeva and Donald R. Mattison and Gary D. V. Hankins and Mahmoud S. Ahmed and Tatiana N. Nanovskaya},
  journal={American journal of obstetrics and gynecology},
  volume={199 2},
OBJECTIVE Determine transplacental transfer and metabolism of 17-alpha-hydroxyprogesterone caproate and its distribution between the tissue and the maternal and fetal circuits of the dually perfused placental lobule. STUDY DESIGN 17-alpha-Hydroxyprogesterone caproate (21 ng/mL) and its dual-labeled isotope, 17-alpha-hydroxy-[(3)H] progesterone [(14)C] caproate were added to the maternal circuit. The concentrations of the drug and its metabolite in trophoblast tissue and both circuits were… CONTINUE READING


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