Transplacental effects of carcinogens and non-carcinogens on activities of pyruvate kinase and lactate dehydrogenase as well as isozymic pattern of LDH in mouse lung.

Abstract

The carcinogens, urethane (URTH), 3-methylcholanthrene (MCA) and dimethylnitrosamine (DMN) given to pregnant mice enhanced permanently the activities of pyruvate kinase (PK) and lactate dehydrogenase (LDH) in the lungs of offspring even well before the appearance of lung tumours. The noncarcinogenic analogues phenylurethane (PHUR) and pyrene (PYR), had no… (More)

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