Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion.

  title={Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion.},
  author={Freda E. Alexander and Sherry L Patheal and Annalisa Biondi and S{\'i}lvia Regina Brandalise and Maria Elena Cabrera and L. M. Chan and Zhinan Chen and Guido Cimino and Jose Carlos C{\'o}rdoba and Long Jun Gu and Hamid Hussein and Eiichi Ishii and Azza Mohamed Kamel and S Labra and Isis Quezado Magalh{\~a}es and Shuki Mizutani and Eleni Petridou and M P De Oliveira and P. S. T. Yuen and Joseph Wiemels and Mel F. Greaves},
  journal={Cancer research},
  volume={61 6},
Infant acute leukemia (IAL) frequently involves breakage and recombination of the MLL gene with one of several potential partner genes. These gene fusions arise in utero and are similar to those found in leukemias secondary to chemotherapy with inhibitors of topoisomerase II (topo-II). This has led to the hypothesis that in utero exposures to chemicals may cause IAL via an effect on topo-II. We report a pilot case-control study of IAL across different countries and ethnic groups. Cases (n = 136… CONTINUE READING
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  • D. Ross
  • Hum. Exp. Toxicol.,
  • 1996
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  • Research. on December
  • 2001
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