Transplacental carcinogenicity of 3'-azido-3'-deoxythymidine in B6C3F1 mice and F344 rats.

@article{Walker2007TransplacentalCO,
  title={Transplacental carcinogenicity of 3'-azido-3'-deoxythymidine in B6C3F1 mice and F344 rats.},
  author={Dale M. Walker and David E. Malarkey and Steven K. Seilkop and Frederick A Ruecker and Kathleen A. Funk and Marilyn J Wolfe and Christopher P Treanor and Julie F Foley and Fletcher F. Hahn and Jerry F. Hardisty and Vernon E. Walker},
  journal={Environmental and molecular mutagenesis},
  year={2007},
  volume={48 3-4},
  pages={283-98}
}
The prophylactic use of zidovudine (3'-azido-3'-deoxythymidine, AZT) during pregnancy greatly reduces transmission of HIV-1 from infected mothers to their infants; however, the affinity of host cell DNA polymerases for AZT also allows for its incorporation into host cell DNA, predisposing to cancer development. To expand upon previous transplacental carcinogenesis assays performed in CD-1 mice, the transplacental carcinogenicity of AZT was evaluated in a second mouse strain and a second rodent… CONTINUE READING