Transplacental and other routes of cancer transmission between individuals.
@article{Tolar2003TransplacentalAO, title={Transplacental and other routes of cancer transmission between individuals.}, author={Jakub Tolar and Joseph P. Neglia}, journal={Journal of pediatric hematology/oncology}, year={2003}, volume={25 6}, pages={ 430-4 } }
Cancer in pregnancy is not rare, and the possibility of transmission of malignancy from mother to child, while infrequent, represents a clinical challenge for the primary pediatric hematologist-oncologist. The authors summarize all reported cases of vertically transmitted cancer and review other reported cases of person-to-person transfer of malignancy. As these cases represent a unique physiologic model of tumor transplantation, the biology of cancer transmission is discussed and provisional…
65 Citations
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Two case reports of pediatric lung cancer resulting from maternal transmission of uterine cervical tumors to their children, who were detected incidentally during analysis of next-generation sequencing results of routine are published.
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The first case of an undifferentiated fetal soft tissue sarcoma involving the maternal compartment of the placenta with metastases to the chorionic villi and the intervillous space is reported.
Transplacental transmission of metastatic melanoma to the posterior fossa. Case report.
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- 2005
The patient was a 7-month-old boy who presented with signs and symptoms of elevated intracranial pressure and required a ventriculoperitoneal shunt for treatment of his hydrocephalus and lived longer than any other patient with transplacental transmission of metastatic melanoma but ultimately died of the disease.
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References
SHOWING 1-10 OF 81 REFERENCES
Transplacental transmission of natural-killer-cell lymphoma.
- MedicineThe New England journal of medicine
- 1999
The placenta is an organ of embryonic origin that supports the growing fetus by facilitating the transfer of nutrients from the mother. It is not well understood how the allogeneic fetus thrives and…
Metastasis of maternal cancer to the placenta and fetus
- MedicineCancer
- 1970
The occurrence of metastasis of maternal cancer to the products of conception is numerically inconsequential but offers an opportunity for significant biological research into the behavior of cancer.…
Transplacental Metastasis of Malignant Melanoma
- Medicine
- 1963
Observations made in this case and three similar ones in the literature suggest that the induction of immunological tolerance during gestation may play a role in the prognosis of tumor disease in the infants.
Transplacental transfer of small-cell carcinoma of the lung.
- MedicineThe New England journal of medicine
- 2002
To the Editor: Although the estimated rate of cancer during pregnancy is 1 case per 1000 live births,1 and placental metastases are not uncommon, transplacental transmission of maternal tumors is r...
Transplacental Melanoma–One-Year Survival
- MedicinePediatrics
- 1976
Another case of transplacental metastatic malignant melanoma is added to those reported in the article by Dr. Trozak et al.
Coexistence of pregnancy and malignancy.
- MedicineThe oncologist
- 2002
This paper reviews the therapeutic and diagnostic management of pregnant patients with cancer, the safety of diagnostic and therapeutic procedures, the metastatic pattern of the maternal tumors to the placenta and fetus, and the potential recommendations for therapeutic abortion.
Maternal malignancy metastatic to the products of conception: a review.
- MedicineObstetrical & gynecological survey
- 1989
A case of maternal large-cell carcinoma of the lung metastatic to the maternal brain and the placenta without fetal involvement is reported.
Fatal Course of Malignant Melanoma During Pregnancy with Dissemination to the Products of Conception
- MedicineActa obstetricia et gynecologica Scandinavica
- 1986
The first case in Denmark of malignant melanoma metastasizing to the placenta and the fetal circulation is presented and the authors would recommend the avoidance of pregnancy within 5 years of treatment of melanoma of any stage.
Transmission of cancer with cadaveric donor organs.
- MedicineJournal of the American Society of Nephrology : JASN
- 1995
The donor origin of the tumor was conclusively demonstrated by the use of polymerase chain reaction of minisatellite regions of donor and recipient DNA, and the transmission of cancer with cadaveric organs may become more frequent as older donors are accepted for organ donation.
CONGENITAL NEUROBLASTOMA INVOLVING THE PLACENTA
- MedicinePediatrics
- 1964
Two cases of placental involvement by congenital metastasizing neuroblastoma are reported, and similarities in the gross and histological appearance of these placentas and those seen in severe isoimmunization disease are discussed.