Transplacental and other routes of cancer transmission between individuals.

@article{Tolar2003TransplacentalAO,
  title={Transplacental and other routes of cancer transmission between individuals.},
  author={Jakub Tolar and Joseph P. Neglia},
  journal={Journal of pediatric hematology/oncology},
  year={2003},
  volume={25 6},
  pages={
          430-4
        }
}
  • J. Tolar, J. Neglia
  • Published 1 June 2003
  • Medicine
  • Journal of pediatric hematology/oncology
Cancer in pregnancy is not rare, and the possibility of transmission of malignancy from mother to child, while infrequent, represents a clinical challenge for the primary pediatric hematologist-oncologist. The authors summarize all reported cases of vertically transmitted cancer and review other reported cases of person-to-person transfer of malignancy. As these cases represent a unique physiologic model of tumor transplantation, the biology of cancer transmission is discussed and provisional… 
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Background Citations
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65 Citations

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Citation Type

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The placental syncytiotrophoblast layer is a barrier that protects the fetus from infection and cancer metastasis, and materno-fetal transmission of leukemia/lymphoma is therefore extremely rare.
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A rare case of transplacental-transmitted maternal melanoma to the placenta and foetus during the second pregnancy of a 28-year-old woman, which regressed spontaneously and the child is now 24 months, alive in complete remission.
Vaginal transmission of cervical cancer from mothers to their newborns
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Two case reports of pediatric lung cancer resulting from maternal transmission of uterine cervical tumors to their children, who were detected incidentally during analysis of next-generation sequencing results of routine are published.
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Metastasis of an undifferentiated fetal soft tissue sarcoma to the maternal compartment of the placenta: maternal aspects, pathology findings and review of the literature on fetal malignancies with placenta metastases
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The first case of an undifferentiated fetal soft tissue sarcoma involving the maternal compartment of the placenta with metastases to the chorionic villi and the intervillous space is reported.
Transplacental transmission of metastatic melanoma to the posterior fossa. Case report.
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The patient was a 7-month-old boy who presented with signs and symptoms of elevated intracranial pressure and required a ventriculoperitoneal shunt for treatment of his hydrocephalus and lived longer than any other patient with transplacental transmission of metastatic melanoma but ultimately died of the disease.
Cancer transmissibility across HLA barriers between immunocompetent individuals: rare but not impossible.
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References

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