Transplacental and other routes of cancer transmission between individuals.

@article{Tolar2003TransplacentalAO,
  title={Transplacental and other routes of cancer transmission between individuals.},
  author={Jakub Tolar and Joseph P. Neglia},
  journal={Journal of pediatric hematology/oncology},
  year={2003},
  volume={25 6},
  pages={
          430-4
        }
}
  • J. Tolar, J. Neglia
  • Published 1 June 2003
  • Medicine
  • Journal of pediatric hematology/oncology
Cancer in pregnancy is not rare, and the possibility of transmission of malignancy from mother to child, while infrequent, represents a clinical challenge for the primary pediatric hematologist-oncologist. The authors summarize all reported cases of vertically transmitted cancer and review other reported cases of person-to-person transfer of malignancy. As these cases represent a unique physiologic model of tumor transplantation, the biology of cancer transmission is discussed and provisional… 
View on PubMed
doi.org
64 Citations
Highly Influential Citations
3
Background Citations
20
Methods Citations
1

64 Citations

Maternal to fetal transmission of cervical carcinoma

TLDR
The imaging findings and clinical course of an unusual case of maternal cervical neuroendocrine carcinoma presenting as bilateral petrous temporal bone lesions in an infant are presented.

Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants.

TLDR
Two cases of pediatric lung cancer resulting from mother-to-infant transmission of uterine cervical tumors were incidentally detected during routine next-generation sequencing of paired samples of tumor and normal tissue, suggesting the existence of alloimmune responses against the transmitted tumors.

A novel mechanism of transplacental cancer transmission: natural killer/T-cell lymphoma in the paratesticular region is of maternal origin.

TLDR
The placental syncytiotrophoblast layer is a barrier that protects the fetus from infection and cancer metastasis, and materno-fetal transmission of leukemia/lymphoma is therefore extremely rare.

Cancer cell transmission via the placenta

TLDR
Three special examples of transmissible animal cancers occurring in utero: maternal to foetus, intraplacental twin to twin leukaemias and choriocarcinoma-extra-embryonic cells to mother are discussed.

Spontaneous regression of transplacental metastases from maternal melanoma in a newborn: case report and review of the literature

TLDR
A rare case of transplacental-transmitted maternal melanoma to the placenta and foetus during the second pregnancy of a 28-year-old woman, which regressed spontaneously and the child is now 24 months, alive in complete remission.

Vaginal transmission of cervical cancer from mothers to their newborns

TLDR
Two case reports of pediatric lung cancer resulting from maternal transmission of uterine cervical tumors to their children, who were detected incidentally during analysis of next-generation sequencing results of routine are published.

The devil is in the details: Genomics of transmissible cancers in Tasmanian devils

TLDR
Transmission dynamics appear consistent with frequency dependence, with DFTD spread by biting during social interactions, resulting in predictions of extinction from standard epidemiological models, and long-infected devil populations persist at reduced densities, suggesting that individual-level variability in fecundity and tumor growth rate in infected individuals are key for understanding epidemiological dynamics.

Metastasis of an undifferentiated fetal soft tissue sarcoma to the maternal compartment of the placenta: maternal aspects, pathology findings and review of the literature on fetal malignancies with placenta metastases

TLDR
The first case of an undifferentiated fetal soft tissue sarcoma involving the maternal compartment of the placenta with metastases to the chorionic villi and the intervillous space is reported.

Transplacental transmission of metastatic melanoma to the posterior fossa. Case report.

TLDR
The patient was a 7-month-old boy who presented with signs and symptoms of elevated intracranial pressure and required a ventriculoperitoneal shunt for treatment of his hydrocephalus and lived longer than any other patient with transplacental transmission of metastatic melanoma but ultimately died of the disease.

Cancer transmissibility across HLA barriers between immunocompetent individuals: rare but not impossible.

...

References

SHOWING 1-10 OF 81 REFERENCES

Transplacental transmission of natural-killer-cell lymphoma.

The placenta is an organ of embryonic origin that supports the growing fetus by facilitating the transfer of nutrients from the mother. It is not well understood how the allogeneic fetus thrives and…

Metastasis of maternal cancer to the placenta and fetus

The occurrence of metastasis of maternal cancer to the products of conception is numerically inconsequential but offers an opportunity for significant biological research into the behavior of cancer.…

Transplacental Metastasis of Malignant Melanoma

TLDR
Observations made in this case and three similar ones in the literature suggest that the induction of immunological tolerance during gestation may play a role in the prognosis of tumor disease in the infants.

Transplacental Melanoma–One-Year Survival

TLDR
Another case of transplacental metastatic malignant melanoma is added to those reported in the article by Dr. Trozak et al.

Coexistence of pregnancy and malignancy.

TLDR
This paper reviews the therapeutic and diagnostic management of pregnant patients with cancer, the safety of diagnostic and therapeutic procedures, the metastatic pattern of the maternal tumors to the placenta and fetus, and the potential recommendations for therapeutic abortion.

Maternal malignancy metastatic to the products of conception: a review.

TLDR
A case of maternal large-cell carcinoma of the lung metastatic to the maternal brain and the placenta without fetal involvement is reported.

Fatal Course of Malignant Melanoma During Pregnancy with Dissemination to the Products of Conception

TLDR
The first case in Denmark of malignant melanoma metastasizing to the placenta and the fetal circulation is presented and the authors would recommend the avoidance of pregnancy within 5 years of treatment of melanoma of any stage.

CONGENITAL NEUROBLASTOMA INVOLVING THE PLACENTA

TLDR
Two cases of placental involvement by congenital metastasizing neuroblastoma are reported, and similarities in the gross and histological appearance of these placentas and those seen in severe isoimmunization disease are discussed.

Cancer in pregnancy: a review of the literature. Part I.

TLDR
A review of the diagnosis, prognosis, and management of cancer during pregnancy in women of childbearing age in the United States finds that in most cases and the pregnancy can be managed concurrently with a good outcome for the baby and without compromising the mother's prognosis.

Maternal Lung Adenocarcinoma Metastatic to the Scalp of a Fetus

TLDR
This report is the first known case of a maternal lung adenocarcinoma metastatic to a fetus, and this patient is alive, well and free of malignancy 5 years after a wide local resection of the scalp and skin grafting.
...