Transplacental and other routes of cancer transmission between individuals.

@article{Tolar2003TransplacentalAO,
  title={Transplacental and other routes of cancer transmission between individuals.},
  author={Jakub Tolar and Joseph P Neglia},
  journal={Journal of pediatric hematology/oncology},
  year={2003},
  volume={25 6},
  pages={
          430-4
        }
}
  • J. Tolar, J. Neglia
  • Published 1 June 2003
  • Medicine
  • Journal of pediatric hematology/oncology
Cancer in pregnancy is not rare, and the possibility of transmission of malignancy from mother to child, while infrequent, represents a clinical challenge for the primary pediatric hematologist-oncologist. The authors summarize all reported cases of vertically transmitted cancer and review other reported cases of person-to-person transfer of malignancy. As these cases represent a unique physiologic model of tumor transplantation, the biology of cancer transmission is discussed and provisional… Expand
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      References

      SHOWING 1-10 OF 81 REFERENCES
      Transplacental transmission of natural-killer-cell lymphoma.
      The placenta is an organ of embryonic origin that supports the growing fetus by facilitating the transfer of nutrients from the mother. It is not well understood how the allogeneic fetus thrives and… Expand
      Metastasis of maternal cancer to the placenta and fetus
      The occurrence of metastasis of maternal cancer to the products of conception is numerically inconsequential but offers an opportunity for significant biological research into the behavior of cancer.… Expand
      Transplacental Metastasis of Malignant Melanoma
      TLDR
      Observations made in this case and three similar ones in the literature suggest that the induction of immunological tolerance during gestation may play a role in the prognosis of tumor disease in the infants. Expand
      Transplacental transfer of small-cell carcinoma of the lung.
      To the Editor: Although the estimated rate of cancer during pregnancy is 1 case per 1000 live births,1 and placental metastases are not uncommon, transplacental transmission of maternal tumors is r...
      Coexistence of pregnancy and malignancy.
      TLDR
      This paper reviews the therapeutic and diagnostic management of pregnant patients with cancer, the safety of diagnostic and therapeutic procedures, the metastatic pattern of the maternal tumors to the placenta and fetus, and the potential recommendations for therapeutic abortion. Expand
      Maternal malignancy metastatic to the products of conception: a review.
      TLDR
      A case of maternal large-cell carcinoma of the lung metastatic to the maternal brain and the placenta without fetal involvement is reported. Expand
      Fatal Course of Malignant Melanoma During Pregnancy with Dissemination to the Products of Conception
      TLDR
      The first case in Denmark of malignant melanoma metastasizing to the placenta and the fetal circulation is presented and the authors would recommend the avoidance of pregnancy within 5 years of treatment of melanoma of any stage. Expand
      Transmission of cancer with cadaveric donor organs.
      TLDR
      The donor origin of the tumor was conclusively demonstrated by the use of polymerase chain reaction of minisatellite regions of donor and recipient DNA, and the transmission of cancer with cadaveric organs may become more frequent as older donors are accepted for organ donation. Expand
      Cancer in pregnancy: a review of the literature. Part I.
      TLDR
      A review of the diagnosis, prognosis, and management of cancer during pregnancy in women of childbearing age in the United States finds that in most cases and the pregnancy can be managed concurrently with a good outcome for the baby and without compromising the mother's prognosis. Expand
      Maternal Lung Adenocarcinoma Metastatic to the Scalp of a Fetus
      TLDR
      This report is the first known case of a maternal lung adenocarcinoma metastatic to a fetus, and this patient is alive, well and free of malignancy 5 years after a wide local resection of the scalp and skin grafting. Expand
      ...
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      3
      4
      5
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