Transperitoneal transport dynamics of methotrexate in vitro: tissue and diffusion barriers.


The importance of the stagnant fluid layers and the mesothelial barrier in the peritoneal absorption and excretion of methotrexate (MTX) in vitro was analysed. In case of intact rabbit parietal peritoneum and a constant fluid flow rate, an asymmetry in the MTX transport and the decrease of its magnitude in time were found. The increase of stirring intensity… (More)


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