Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models.

@article{Choi2014TransnitrosylationFD,
  title={Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models.},
  author={Min Sik Choi and Tomohiro Nakamura and Seung-Je Cho and Xuemei Han and Emily A. Holland and Jing Qu and Gregory A. Petsko and John R. Yates and Robert C. Liddington and Stuart Lipton},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2014},
  volume={34 45},
  pages={15123-31}
}
Emerging evidence suggests that oxidative/nitrosative stress, as occurs during aging, contributes to the pathogenesis of Parkinson's disease (PD). In contrast, detoxification of reactive oxygen species and reactive nitrogen species can protect neurons. DJ-1 has been identified as one of several recessively inherited genes whose mutation can cause familial PD, and inactivation of DJ-1 renders neurons more susceptible to oxidative stress and cell death. DJ-1 is also known to regulate the activity… CONTINUE READING