Corpus ID: 44861352

Transnitrosation as a predominant mechanism in the hypotensive effect of S-nitrosoglutathione.

@article{Park1993TransnitrosationAA,
  title={Transnitrosation as a predominant mechanism in the hypotensive effect of S-nitrosoglutathione.},
  author={J. Park and G. Billman and G. Means},
  journal={Biochemistry and molecular biology international},
  year={1993},
  volume={30 5},
  pages={
          885-91
        }
}
S-Nitrosoglutathione, a possible intermediate in the pharmacological mechanisms of many vasodilators, undergoes hemolysis at pH 7.4 and 37 degrees C to give oxidized glutathione and nitric oxide with a second-order rate constant of approximately 3 x 10(-4) M-1sec-1. At the dosages normally employed, this reaction is, therefore, too slow to be an obligatory step in the pharmacological mechanisms of those, usually, fast-acting drugs. Transfers of the nitroso moiety to another thiol or to certain… Expand
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S-nitrosothiols in Cell Signaling
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