Transneuronal degeneration in the spread of Alzheimer's disease pathology: immunohistochemical evidence for the transmission of tau hyperphosphorylation.

@article{Su1997TransneuronalDI,
  title={Transneuronal degeneration in the spread of Alzheimer's disease pathology: immunohistochemical evidence for the transmission of tau hyperphosphorylation.},
  author={Joseph H. Su and Gonghua Deng and Carl Cotman},
  journal={Neurobiology of disease},
  year={1997},
  volume={4 5},
  pages={365-75}
}
Neurofibrillary tangles and dystrophic neurites appear to develop in a highly characteristic spatial and temporal sequence in AD. In order to examine the nature of the cellular progression we have studied the trisynaptic entorhinal, dentate gyrus, CA3/4 circuit, using an antibody to hyperphosphorylated tau which is a biochemical marker for tangle formation… CONTINUE READING