Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts.

@article{Zicha2004TransmuralEO,
  title={Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts.},
  author={Stephen Zicha and Ling Xiao and Sara G Stafford and Tae Joon Cha and Wei Han and Andr{\'a}s Varr{\'o} and Stanley Nattel},
  journal={The Journal of physiology},
  year={2004},
  volume={561 Pt 3},
  pages={735-48}
}
The transient outward current (I(to)), an important contributor to transmural electrophysiological heterogeneity, is significantly remodelled in congestive heart failure (CHF). The molecular bases of transmural I(to) gradients and CHF-dependent ionic remodelling are incompletely understood. To elucidate these issues, we studied mRNA and protein expression of Kv4.3 and KChIP2, the principal alpha and beta subunits believed to form I(to), in epicardial and endocardial tissues and in isolated… CONTINUE READING
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