Transmitter release increases intracellular calcium in perisynaptic schwann cells in situ

@article{Jahromi1992TransmitterRI,
  title={Transmitter release increases intracellular calcium in perisynaptic schwann cells in situ},
  author={Babak S. Jahromi and Richard Robitaille and Milton P. Charlton},
  journal={Neuron},
  year={1992},
  volume={8},
  pages={1069-1077}
}
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References

SHOWING 1-10 OF 43 REFERENCES
Voltage-dependent calcium and potassium channels in retinal glial cells
TLDR
It is shown that Müller cells, the principal glial cells of the vertebrate retina, can generate ‘Ca2+spikes’ in freshly excised slices of retinal tissue and the presence of voltage-dependent ion channels may enhance the ability of Müllers cells to regulate extracellular K+ levels in the retina and may be involved in the generation of the electroretinogram.
Presynaptic calcium signals and transmitter release are modulated by calcium-activated potassium channels
TLDR
The results are consistent with the hypothesis that CTX-sensitive gKca channels normally narrow the presynaptic action potential and thus, by indirectly regulating Ca2+ entry, can serve as powerful modulators of evoked transmitter release.
Facilitation of voltage-gated ion channels in frog neuroglia by nerve impulses
TLDR
It is reported that nerve impulses in the axons of the frog optic nerve transiently alter the properties of the voltage-dependent membrane channels of the surface glial cells (astrocytes), a demonstration of a new form of neuron-glia interaction.
Induced transmitter release from Schwann cells and its suppression by actinomycin D.
TLDR
AT neuromuscular junctions of vertebrates, quanta of acetylcholine (ACh) are continuously being released from nerve endings, which gives rise to miniature end-plate potentials which can be recorded intracellularly from the muscle fibre.
Signalling Between Neuronal and Glial Cells
TLDR
The maintenance of normal nervous system function appears to involve continuous communication between neurons and their associated cells, the neuroglia, but for the most part the specific signalling processes are poorly defined and their physiological significance obscure.
Glutamate induces calcium waves in cultured astrocytes: long-range glial signaling.
TLDR
It is reported that cultured hippocampal astrocytes can respond to glutamate with a prompt and oscillatory elevation of cytoplasmic free calcium, visible through use of the fluorescent calcium indicator fluo-3.
Effect of nerve impulses on the membrane potential of glial cells in the central nervous system of amphibia.
TLDR
In the central nervous system of the leech, which contains smooth muscle cells in its connective tissue capsule, the effect of massive neuronal activity on the resting potential of glial cells could not be studied adequately because the preparation under these conditions dislodged the electrode.
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