Transmitter release from Rana pipiens vestibular hair cells via mGluRs: a role for intracellular Ca(++) release.

@article{Hendricson2002TransmitterRF,
  title={Transmitter release from Rana pipiens vestibular hair cells via mGluRs: a role for intracellular Ca(++) release.},
  author={Adam W Hendricson and Paul S. Guth},
  journal={Hearing research},
  year={2002},
  volume={172 1-2},
  pages={
          99-109
        }
}
The response of the semicircular canal (SCC) to the group I mGluR-selective agonist dihydroxyphenylglycine (DHPG; 300 microM) - facilitation of afferent discharge rate - was dose-dependently reduced by the phospholipase C inhibitor U-73122 (1-100 microM; IC(50): 22 microM), the smooth endoplasmic reticulum Ca(++) ATPase inhibitor thapsigargin (100 nM-3 microM; IC(50): 500 nM), and xestospongin C (100 pM-1 microM; IC(50): 11 nM), an inositol trisphosphate receptor (IP(3)R) antagonist. Ryanodine… CONTINUE READING