Transmitter-mediated inhibition of N-type calcium channels in sensory neurons involves multiple GTP-binding proteins and subunits

@article{DiversPierluissi1995TransmittermediatedIO,
  title={Transmitter-mediated inhibition of N-type calcium channels in sensory neurons involves multiple GTP-binding proteins and subunits},
  author={Mar{\'i}a A Divers{\'e}-Pierluissi and Paul K. Goldsmith and Kathleen Dunlap},
  journal={Neuron},
  year={1995},
  volume={14},
  pages={191-200}
}
The modulation of voltage-activated Ca2+ channels by neurotransmitters and peptides is very likely a primary means of regulating Ca(2+)-dependent physiological functions such as neurosecretion, muscle contraction, and membrane excitability. In neurons, N-type Ca2+ channels (defined as omega-conotoxin GVIA-sensitive) are one prominent target for transmitter-mediated inhibition. This inhibition is widely thought to result from a shift in the voltage independence of channel gating. Recently… CONTINUE READING