Transmitter-like 3,4-dihydroxyphenylalanine is tonically released by nicotine in striata of conscious rats.

@article{Nakamura1992Transmitterlike3I,
  title={Transmitter-like 3,4-dihydroxyphenylalanine is tonically released by nicotine in striata of conscious rats.},
  author={Shin Nakamura and Yoshio Goshima and Jianying Yue and Takeaki Miyamae and Yoshimi Misu},
  journal={European journal of pharmacology},
  year={1992},
  volume={222 1},
  pages={75-80}
}
Microdialysis and high performance liquid chromatography with an electrochemical detector were applied to compare the characteristics of nicotine-evoked release of endogenous 3,4-dihydroxyphenylalanine (DOPA) from striata of conscious rats and those of the release of dopamine (DA). Dialysates were collected every 20 min 3-8 h after the start of perfusion. Nicotine was perfused for 20 min through a probe. (+/-)-Nicotine (100-300 microM) constantly and repeatedly released DOPA and DA over a… CONTINUE READING