Transmission of systemic AA amyloidosis in animals.

  title={Transmission of systemic AA amyloidosis in animals.},
  author={Tomoaki Murakami and Naotaka Ishiguro and Keiichi Higuchi},
  journal={Veterinary pathology},
  volume={51 2},
Amyloidoses are a group of protein-misfolding disorders that are characterized by the deposition of amyloid fibrils in organs and/or tissues. In reactive amyloid A (AA) amyloidosis, serum AA (SAA) protein forms deposits in mice, domestic and wild animals, and humans that experience chronic inflammation. AA amyloid fibrils are abnormal β-sheet-rich forms of the serum precursor SAA, with conformational changes that promote fibril formation. Extracellular deposition of amyloid fibrils causes… CONTINUE READING
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