Transmission of innate immune signaling by packaging of cGAMP in viral particles.

Abstract

Infected cells detect viruses through a variety of receptors that initiate cell-intrinsic innate defense responses. Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS) is a cytosolic sensor for many DNA viruses and HIV-1. In response to cytosolic viral DNA, cGAS synthesizes the second messenger 2'3'-cyclic GMP-AMP (cGAMP… (More)
DOI: 10.1126/science.aab3628

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Cite this paper

@article{Gentili2015TransmissionOI, title={Transmission of innate immune signaling by packaging of cGAMP in viral particles.}, author={Matteo Gentili and Joanna Kowal and Mercedes Tkach and Takeshi Satoh and Xavier Lahaye and C{\'e}cile Conrad and Marilyn Boyron and B erang ere Lombard and Sylv{\`e}re Durand and Guido Kroemer and Damarys Loew and Marc Dalod and Clotilde Th{\'e}ry and Nicolas Manel}, journal={Science}, year={2015}, volume={349 6253}, pages={1232-6} }