Transmission of human T-cell leukemia virus type 1 to mice.

  title={Transmission of human T-cell leukemia virus type 1 to mice.},
  author={Jianguang Fang and Shigeki Kushida and Renqing Feng and Masakazu Tanaka and Tatsuyoshi Kawamura and Hisashi Abe and Naoyoshi Maeda and M Onobori and M Hori and Kazuhiko Uchida and Masanao Miwa},
  journal={Journal of virology},
  volume={72 5},
Human T-cell leukemia virus type 1 (HTLV-1) is associated with adult T-cell leukemia/lymphoma, HTLV-1-associated myelopathy/tropical spastic paraparesis, and other diseases. For prevention of the transmission of HTLV-1 and manifestation of these diseases, a small-animal model, especially a mouse model, would be useful. We injected HTLV-1-producing T cells (MT-2) intraperitoneally into neonatal C3H/HeJ mice. While the antibody against HTLV-1 antigens was not detectable in C3H/HeJ mice, HTLV-1… CONTINUE READING


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