Transmission of allostery through the lectin domain in selectin-mediated cell adhesion.

@article{Waldron2009TransmissionOA,
  title={Transmission of allostery through the lectin domain in selectin-mediated cell adhesion.},
  author={Travis Tyson Waldron and Timothy A Springer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 1},
  pages={85-90}
}
The selectins are cell adhesion proteins that must resist applied forces to mediate leukocyte tethering and rolling along the endothelium and have 2 conformational states. Selectin-ligand bond dissociation increases only modestly with applied force, and exhibits catch bond behavior in a low-force regime where bond lifetimes counterintuitively increase with increasing force. Both allosteric and sliding-rebinding models have emerged to explain catch bonds. Here, we introduce a large residue into… CONTINUE READING
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