Transmission of Toxoplasma gondii from infected dendritic cells to natural killer cells.

@article{Persson2009TransmissionOT,
  title={Transmission of Toxoplasma gondii from infected dendritic cells to natural killer cells.},
  author={Catrine M. Persson and Henrik Lambert and Polya P Vutova and Isabel Dellacasa-Lindberg and Joanna Nederby and H. Yagita and H O Ljunggren and Alf Grandien and Antonio Barragan and Benedict J Chambers},
  journal={Infection and immunity},
  year={2009},
  volume={77 3},
  pages={970-6}
}
The obligate intracellular parasite Toxoplasma gondii can actively infect any nucleated cell type, including cells from the immune system. In the present study, we observed that a large number of natural killer (NK) cells were infected by T. gondii early after intraperitoneal inoculation of parasites into C57BL/6 mice. Interestingly, one mechanism of NK cell infection involved NK cell-mediated targeting of infected dendritic cells (DC). Perforin-dependent killing of infected DC led to active… CONTINUE READING