Transmission of Hypervirulence Traits via Sexual Reproduction within and between Lineages of the Human Fungal Pathogen Cryptococcus gattii

@inproceedings{Voelz2013TransmissionOH,
  title={Transmission of Hypervirulence Traits via Sexual Reproduction within and between Lineages of the Human Fungal Pathogen Cryptococcus gattii},
  author={Kerstin Voelz and Hansong Ma and Sujal Phadke and Edmond J. Byrnes and Pinkuan Zhu and Olaf Mueller and Rhys A. Farrer and Daniel A. Henk and Yonathan Lewit and Yen-Ping Hsueh and Matthew C. Fisher and Alexander Idnurm and Joseph Heitman and Robin C May},
  booktitle={PLoS genetics},
  year={2013}
}
Since 1999 a lineage of the pathogen Cryptococcus gattii has been infecting humans and other animals in Canada and the Pacific Northwest of the USA. It is now the largest outbreak of a life-threatening fungal infection in a healthy population in recorded history. The high virulence of outbreak strains is closely linked to the ability of the pathogen to undergo rapid mitochondrial tubularisation and proliferation following engulfment by host phagocytes. Most outbreaks spread by geographic… CONTINUE READING
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