Transmission of HTLV-III infection from human plasma to chimpanzees: an animal model for AIDS.

@article{Alter1984TransmissionOH,
  title={Transmission of HTLV-III infection from human plasma to chimpanzees: an animal model for AIDS.},
  author={Harvey J. Alter and Jorg W. Eichberg and Henry Masur and W. Carl Saxinger and Robert L Gallo and Abe M. Macher and H. Clifford Lane and Anthony S. Fauci},
  journal={Science},
  year={1984},
  volume={226 4674},
  pages={549-52}
}
Two of three chimpanzees given plasma from patients with acquired immune deficiency syndrome (AIDS) or pre-AIDS showed serum antibodies to type III human T-cell leukemia virus (HTLV-III) 10 to 12 weeks after transfusion. One animal also developed lymphadenopathy, transient depression of the ratio of T4 to T8 lymphocytes, and impaired blastogenic responses. No opportunistic infections occurred. Adenopathy persisted for 32 weeks, and antibody to HTLV-III persisted for at least 48 weeks. This… CONTINUE READING

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