Transmission of HIV-1 and HLA-B allele-sharing within serodiscordant heterosexual Zambian couples.

@article{Dorak2004TransmissionOH,
  title={Transmission of HIV-1 and HLA-B allele-sharing within serodiscordant heterosexual Zambian couples.},
  author={Mehmet Tevfik Dorak and Jianming Tang and Ana Penman-Aguilar and Andrew O. Westfall and Isaac S Zulu and Elena S Lobashevsky and Nzali G. Kancheya and Margaret M Schaen and Susan A. Allen and Richard A. Kaslow},
  journal={Lancet},
  year={2004},
  volume={363 9427},
  pages={2137-9}
}
Factors that might increase risk of HIV-1 transmission include age, sex, and amount of HIV-1 RNA in plasma, but findings for HLA allele-sharing are not in agreement. We tested the hypothesis that allele sharing at HLA loci is associated with increased risk of transmission of HIV-1 infection in cohabiting heterosexual Zambian couples. We studied 125… CONTINUE READING