Transmission electron microscopy of cortical dendritic spines in the human oedematous cerebral cortex.

@article{Castejn2004TransmissionEM,
  title={Transmission electron microscopy of cortical dendritic spines in the human oedematous cerebral cortex.},
  author={Orlando Jos{\'e} Castej{\'o}n and Alan Castellano and G J Arismendi},
  journal={Journal of submicroscopic cytology and pathology},
  year={2004},
  volume={36 2},
  pages={181-91}
}
The cortical biopsies of 31 patients with clinical diagnosis of congenital hydrocephalus, vascular anomalies, brain tumours and brain trauma were examined with the transmission electron microscope. A variety of swollen spine shapes were found: mushroom shaped, filopodic, lanceolated spines, and megaspines. The spines appeared axonless or making asymmetric synaptic contacts with swollen presynaptic axons. They exhibited a disrupted actin-like network, dilated endoplasmic reticulum profiles… CONTINUE READING