Transmission disequilibrium mapping at the serotonin transporter gene (SLC6A4) region in autistic disorder

@article{Kim2002TransmissionDM,
  title={Transmission disequilibrium mapping at the serotonin transporter gene (SLC6A4) region in autistic disorder},
  author={Sung-jin Kim and Nancy J. Cox and Rachel Y Courchesne and C. Lord and Christina Corsello and Natasha Akshoomoff and Stephen J. Guter and Bennett L. Leventhal and Eric Courchesne and E H Cook},
  journal={Molecular Psychiatry},
  year={2002},
  volume={7},
  pages={278-288}
}
The serotonin transporter gene (SLC6A4, MIM 182138) is a candidate gene in autistic disorder based on neurochemical, neuroendocrine studies and the efficacy of potent serotonin transporter inhibitors in reducing ritualistic behaviors and related aggression. An insertion/deletion polymorphism (5-HTTLPR) in the promoter region and a variable number of tandem repeat polymorphism (VNTR) in the second intron, were previously identified and suggested to modulate transcription. Six previous family… CONTINUE READING

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References

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Showing 1-10 of 50 references

A genome wide screen for autism : strong evidence for linkage to chromosomes 2 q , 7 q and 16 p

  • C Lord, M Rutter, A LeCouteur
  • Am J Hum Genet
  • 2001

Role of the serotonin transporter in the behavioral expression of autism

  • S Tordjman, L Gutneckt, M Carlier, E Spitz, C Antoine, F Slama
  • Mol Psychiatry
  • 2001

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