Transmission-dependent tolerance to multiclonal Plasmodium falciparum infection.

@article{Frnert2009TransmissiondependentTT,
  title={Transmission-dependent tolerance to multiclonal Plasmodium falciparum infection.},
  author={Anna F{\"a}rnert and Thomas N Williams and Tabitha Wanja Mwangi and Anna G C Ehlin and Greg W Fegan and Alex W Macharia and Brett Lowe and Scott Montgomery and Kevin Marsh},
  journal={The Journal of infectious diseases},
  year={2009},
  volume={200 7},
  pages={
          1166-75
        }
}
Whether the number of concurrent clones in asymptomatic Plasmodium falciparum infections reflects the degree of host protection was investigated in children living in areas with different levels of transmission on the coast of Kenya. The number of concurrent clones was determined on the basis of polymorphism in msp2, which encodes the vaccine candidate antigen merozoite surface protein 2. In a low-transmission area, most children had monoclonal infections, and diversity did not predict a risk… CONTINUE READING

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