Transmission bottlenecks and the evolution of fitness in rapidly evolving RNA viruses.

@article{Elena2001TransmissionBA,
  title={Transmission bottlenecks and the evolution of fitness in rapidly evolving RNA viruses.},
  author={Santiago F. Elena and Rafael Sanju{\'a}n and Antonio V. Border{\'i}a and Paul E Turner},
  journal={Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases},
  year={2001},
  volume={1 1},
  pages={41-8}
}
We explored the evolutionary importance of two factors in the adaptation of RNA viruses to their cellular hosts, size of viral inoculum used to initiate a new infection, and mode of transmission (horizontal versus vertical). Transmission bottlenecks should occur in natural populations of viruses and their profound effects on viral adaptation have been previously documented. However, the role of transmission mode has not received the same attention. Here we used a factorial experimental design… CONTINUE READING

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