Transmission and age-at-onset patterns in familial Alzheimer's disease: evidence for heterogeneity.

@article{Farrer1990TransmissionAA,
  title={Transmission and age-at-onset patterns in familial Alzheimer's disease: evidence for heterogeneity.},
  author={Lindsay A. Farrer and Richard H. Myers and L. Adrienne Cupples and Peter St George-Hyslop and Thomas Bird and Martin Rossor and Michael J. Mullan and Ronald J. Polinsky and Linda Nee and Lee Heston},
  journal={Neurology},
  year={1990},
  volume={40 3 Pt 1},
  pages={395-403}
}
We evaluated age at onset and lifetime risk for Alzheimer's disease (AD) in 70 kindreds with familial AD (designated FAD) composed of 541 affected and 1,066 unaffected offspring of demented parents who were identified retrospectively. Using a survival analysis method which takes into account affected persons with unknown onset ages and unaffected persons with unknown censoring ages, we found lifetime risk of AD among at-risk offspring by age 87 to be 64%. Analysis of age at onset among kindreds… CONTINUE READING

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