Transmission Distortion Affecting Human Noncrossover but Not Crossover Recombination: A Hidden Source of Meiotic Drive

@inproceedings{OdenthalHesse2014TransmissionDA,
  title={Transmission Distortion Affecting Human Noncrossover but Not Crossover Recombination: A Hidden Source of Meiotic Drive},
  author={Linda Odenthal-Hesse and Ingrid L. Berg and Amelia Veselis and Alec John Jeffreys and Celia A May},
  booktitle={PLoS genetics},
  year={2014}
}
Meiotic recombination ensures the correct segregation of homologous chromosomes during gamete formation and contributes to DNA diversity through both large-scale reciprocal crossovers and very localised gene conversion events, also known as noncrossovers. Considerable progress has been made in understanding factors such as PRDM9 and SNP variants that influence the initiation of recombination at human hotspots but very little is known about factors acting downstream. To address this, we… CONTINUE READING
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