Transmissible spongiform encephalopathy diagnosis using PrPsc immunohistochemistry on fixed but previously frozen brain samples.

@article{Debeer2002TransmissibleSE,
  title={Transmissible spongiform encephalopathy diagnosis using PrPsc immunohistochemistry on fixed but previously frozen brain samples.},
  author={Sabine O S Debeer and Thierry Baron and Anna A. Bencsik},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={2002},
  volume={50 5},
  pages={611-6}
}
The histological diagnosis of transmissible spongiform encephalopathies (TSEs), such as scrapie and bovine spongiform encephalopathy (BSE), relies on identification in the brain of spongiosis, gliosis, and neuron loss without inflammatory lesions. Because of its sensitivity, immunohistochemistry of abnormal prion protein (PrPsc) is of great help in this… CONTINUE READING