Transmissible spongiform encephalopathies.

@article{Liemann1998TransmissibleSE,
  title={Transmissible spongiform encephalopathies.},
  author={Susanne Liemann and Rudi Glockshuber},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={250 2},
  pages={187-93}
}
Scrapie, bovine spongiform encephalopathy (BSE), and the Creutzfeldt-Jakob disease (CJD) belong to a group of lethal neurodegenerative disorders in mammals. Prion diseases or transmissible spongiform encephalopathies (TSEs) are characterized by the accumulation of an abnormal isoform (PrPSc) of the host-encoded cellular prion protein (PrPC) in the brain. The infectious agent, the 'prion,' is believed to be devoid of informational nucleic acid and to consist largely, if not entirely, of PrPSc… CONTINUE READING

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