Transmissibility of Atypical Scrapie in Ovine Transgenic Mice: Major Effects of Host Prion Protein Expression and Donor Prion Genotype

@inproceedings{Arsac2009TransmissibilityOA,
  title={Transmissibility of Atypical Scrapie in Ovine Transgenic Mice: Major Effects of Host Prion Protein Expression and Donor Prion Genotype},
  author={Jean-No{\"e}l Arsac and Dominique B{\'e}temps and Eric Morignat and C{\'e}cile F{\'e}raudet and Anna A. Bencsik and Denise Aubert and J acques Grassi and Thierry Baron},
  booktitle={PloS one},
  year={2009}
}
Atypical scrapie or Nor98 has been identified as a transmissible spongiform encephalopathy (TSE) that is clearly distinguishable from classical scrapie and BSE, notably regarding the biochemical features of the protease-resistant prion protein PrP(res) and the genetic factors involved in susceptibility to the disease. In this study we transmitted the… CONTINUE READING