Transmigration of human ovarian adenocarcinoma cells through endothelial extracellular matrix involves alphav integrins and the participation of MMP2.

@article{LeroyDudal2005TransmigrationOH,
  title={Transmigration of human ovarian adenocarcinoma cells through endothelial extracellular matrix involves alphav integrins and the participation of MMP2.},
  author={Johanne Leroy-Dudal and Christine Demeilliers and Olivier Gallet and E. Pauthe and Soizic Dutoit and R{\'e}my Agniel and Pascal Gauduchon and Franck Carreiras},
  journal={International journal of cancer},
  year={2005},
  volume={114 4},
  pages={531-43}
}
The growth of ovarian carcinoma is dependent upon their vascularistion, but the interaction of ovarian cancer cells with the endothelium and their invasion through an endothelial environment remain poorly understood at the molecular level. To investigate adhesive events underlying this process with focusing on the role of alphav integrins and MT1MMP-MMP2 proteinases, we used in vitro models of cocultures of human ovarian adenocarcinoma cell lines (IGROV1 and SKOV3) with human umbilical vein… CONTINUE READING

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