Transmembrane transport of peptidoglycan precursors across model and bacterial membranes.

  title={Transmembrane transport of peptidoglycan precursors across model and bacterial membranes.},
  author={Vincent van Dam and Robert Sijbrandi and Matthijs A Kol and Ewa Swiezewska and Ben de Kruijff and Eefjan Breukink},
  journal={Molecular microbiology},
  volume={64 4},
Translocation of the peptidoglycan precursor Lipid II across the cytoplasmic membrane is a key step in bacterial cell wall synthesis, but hardly understood. Using NBD-labelled Lipid II, we showed by fluorescence and TLC assays that Lipid II transport does not occur spontaneously and is not induced by the presence of single spanning helical transmembrane peptides that facilitate transbilayer movement of membrane phospholipids. MurG catalysed synthesis of Lipid II from Lipid I in lipid vesicles… CONTINUE READING
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