Transmembrane signalling mechanisms regulating expression of cationic amino acid transporters and inducible nitric oxide synthase in rat vascular smooth muscle cells.

@article{Baydoun1999TransmembraneSM,
  title={Transmembrane signalling mechanisms regulating expression of cationic amino acid transporters and inducible nitric oxide synthase in rat vascular smooth muscle cells.},
  author={Anwar R. Baydoun and Samantha M Wileman and Caroline P. D. Wheeler-Jones and Michael Marber and Giovanni E. Mann and Jeremy D. Pearson and Ellen Ildicho Closs},
  journal={The Biochemical journal},
  year={1999},
  volume={344 Pt 1},
  pages={265-72}
}
The signalling mechanisms involved in the induction of nitric oxide synthase and l-arginine transport were investigated in bacterial lipopolysaccharide (LPS)- and interferon-gamma (IFN-gamma)-stimulated rat cultured aortic smooth muscle cells (RASMCs). The expression profile of transcripts for cationic amino acid transporters (CATs) and their regulation by LPS and IFN-gamma were also examined. Control RASMCs expressed mRNA for CAT-1, CAT-2A and CAT-2B. Levels of all three transcripts were… CONTINUE READING

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