Transmembrane signaling through phospholipase C in cortical and hippocampal membranes of psychogenetically selected rat lines

Abstract

Rationale: One of the major pathways for neurotransmitter signaling involves phosphoinositide-specific and G-protein-dependent phospholipase C-β (PLC-β), which stimulates the formation of inositol 1,4,5-trisphosphate and diacylglycerol. Serotonergic and muscarinic-cholinergic signals in the brain are largely mediated through the hydrolysis of… (More)
DOI: 10.1007/s002130000621

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